I'm usually pretty good about getting around to everything I want to play, even if it takes a couple of years to do so. That said, there are some games (widely regarded as being excellent interactive experiences) I will never work up the motivation for despite being right up my alley. Here are a few examples.
rotoscope animation. The only other game that I'm aware of that used this technique in a non-trivial way is The Banner Saga. Obviously, it's rare to see this kind of animation technique anywhere because of how resource intensive it is. Typically, it's used sparingly, such as in short segments or in the case of The Last Express few frames of animation per second. The lowest I've heard a cartoon can get away with, regarding FPS, is somewhere between six and twelve. The Last Express mostly gets by with two to three, with only a few scenes having more. The overall effect is like watching a rapid slideshow, which some claim is evocative of the timeperoid. For me though, it's practically unbearable to watch for more than a few minutes at a time.
So, there you have it. Those are three great games I will never play; not because it would be impossible, but rather because I can't justify the time/money/effort required to myself. Call me lazy. Call me picky. Call me ignorant...or maybe the root of it is an embarrassment of riches when it comes to games to play...now please excuse me while I dive into more Hollow Knight, Doom 3, Dark Souls 3, Shadow of Mordor, Cultist Simulator and Dragon Quest Builders.